Immune system is altered with biological clock

• April 16, 2024

Researchers of the Yale University School of Medicine they discovered that a protein from immune system , called TLR9, is altered by the chemical changes that occur in the organism with the biological clock.

In the study, published in the journal Immunity, it is emphasized that the intensity of a infection It depends on the time of day. So that the immune system can attack an infection you need to first detect the invading pathogen.

The specialists analyzed that the Toll-type receptor 9 (TLR9) can identify the DNA of the bacteria Y virus . The amount of this protein and its function is controlled by the organism's biological clock, which changes throughout the day.

In the experiment with mice, it was observed that the response of the immune system improved when rodents were immunized at the time of maximum TLR9 activity

Professor Erol Fikrig, who led the research, noted that the "direct molecular link between circadian rhythms and immune system , could have important implications for the prevention and treatment of diseases ".

The implications for health care are important since this finding could mean that drugs must be delivered at a certain time of day so they can be more effective.

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Video Medicine: How Your Circadian Rhythms Impact Your Microbes | John Douillard's LifeSpa (April 2024).